Several antioxidant experiments demonstrated the antioxidant activity of polysaccharides and polysaccharide complexes extracted from G. lucidum. Various in-vitro antioxidant assays confirmed the antioxidant potential. [1]
The G. lucidum polysaccharides demonstrated an antioxidant influence in in-vitro investigations. They enhanced the activity of antioxidant enzymes (SOD, CAT, and GPx) and reduced the production of IL-1, IL-6, and TNF in rats with cervical cancer. [2]
The extract of G. lucidum exhibited significant antioxidant and lipid peroxidation inhibitory action. [3]
Polysaccharides extracted from G. lucidum have antioxidant action and protect tissues against the toxicity of reactive oxygen species. They also contribute to the body’s oxidative condition [4].
The methanolic extracts isolated from G. lucidum have been demonstrated to prevent kidney damage by restoring the kidneys’ antioxidant defense system. [3]
G. lucidum polysaccharides raised the number of white blood cells and lymphocytes. Serum IgG and IgA immunoglobulin amounts were also measured, and increased IgA levels were found [5].
A study examined natural polysaccharides and degraded polysaccharides by the ultrasonic process and analyzed their hypolipidemic and antioxidant properties. G. lucidum polysaccharides have been found to exhibit biological activity against superoxide dismutase and glutathione peroxidase. [6]

Polysaccharides from G. lucidum have been demonstrated to boost non-enzymatic and enzymatic antioxidants, serum insulin levels, and lipid peroxidation. [7]
According to one study, the terpene fraction had the most antioxidants: ganoderic acids A, B, C, and D, lucidic acid B, and ganodermanontriol. [8]
G. lucidum promotes for the protection of cellular constituents from oxidative damage in order to reduce the potential of mutation and carcinogenesis. [9]
G. lucidum, substances, especially polysaccharides and triterpenoids, exhibit antioxidant action. Polysaccharides mainly guard immune cells and DNA from oxidative damage. [9]

References

[1] Bukhman, V. M., Treshchalina, E. M., Krasnopol’skaia, L. M., Isakova, E. B., Sedakova, L. A., Avtonomova, A. V., et al. (2007). Preparation and biological properties of basidiomycete aqueous extracts and their mycelial compositions. Antibiot. Khimioter 52, 4–9
[2] XiaoPing, C., Yan, C., ShuiBing, L., YouGuo, C., JianYun, L., and LanPing, L. (2009). Free radical scavenging of Ganoderma lucidum polysaccharides and its effect on antioxidant enzymes and immunity activities in cervical carcinoma rats. Carbohydr. Polym. 77, 389–393. doi:10.1016/j.carbpol.2009.01.009
[3] Sheena, N., Ajith, T. A., and Janardhanan, K. K. (2003a). Anti-inflammatory and anti-nociceptive activities of Ganoderma lucidum occurring in south India. Pharm. Biol. 41, 301–304. doi:10.1076/phbi.41.4.301.15677
[4] Jeong, Y. U., and Park, Y. J. (2020). Ergosterol peroxide from the medicinal mushroom Ganoderma lucidum inhibits differentiation and lipid accumulation of 3T3-L1 adipocytes. Int. J. Mol. Sci. 21, 460. doi:10.3390/ijms21020460
[5] Li, J., Gu, F., Cai, C., Hu, M., Fan, L., Hao, J., et al. (2020). Purification, structural characterization, and immunomodulatory activity of the polysaccharides from Ganoderma lucidum. Int. J. Biol. Macromol. 143, 806–813. doi:10.1016/j. ijbiomac.2019.09.141
[6] Xu, Y., Zhang, X., Yan, X. H., Zhang, J. L., Wang, L. Y., Xue, H., et al. (2019). Characterization, hypolipidemic and antioxidant activities of degraded polysaccharides from Ganoderma lucidum. Int. J. Biol. Macromol. 135, 706–716. doi:10.1016/j.ijbiomac.2019.05.166
[7] Jiang, H., Sun, P., He, J., and Shao, P. (2012). Rapid purification of polysaccharides using novel radial flow ion-exchange by response surface methodology from Ganoderma lucidum. Food Bioprod. Process. 90, 1–8. doi:10. 1016/j.fbp.2010.12.001
[8] Zhu, M., Chang, Q., Wong, L. K., Chong, F. S., and Li, R. C. (1999). Triterpene antioxidants from Ganoderma lucidum. Phytother. Res. 13, 529–531. doi:10.1002/ (sici)1099-1573(199909)13:63.0.co;2-x
[9] Xu, T., Beelman, R.B., 2015. The bioactive compounds in medicinal mushrooms have potential protective effects against neurodegenerative diseases. Adv. Food Technol. Nutr. Sci. Open J. 1 (2), 62–65