Anti-bacterial activity of G. Lucidium

Polysaccharides, terpenes, and lectins are antimicrobial substances that interfere with the cell membrane of bacteria. G. lucidum has all these chemicals that can inhibit both gram-positive and gram-negative bacteria. [1]
An aqueous extract of G. lucidum, can inhibit 15 different gram-positive and gram-negative bacteria. Some compounds, such as triterpenoids and ganomycin, have been demonstrated to have broad antibacterial action [2].
G. lucidum culture fluids have antibacterial efficacy against bacterial plant infections [3]
G. lucidum hot water extract was used to create unique, health-promoting kombucha products. Microbes such as S. epidermidis, B. cereus, Rhodococcus equi, and R. equi were all suppressed by the liquid G. lucidum beverage. [4]
G. lucidum extracts inhibited E. coli and P. aeruginosa. [5]
G. lucidum peptides demonstrated higher antibacterial activity against E. coli and Salmonella typhi. [6]
A study found that a component of G. lucidum had high effectiveness against Methicillin-Resistant S. aureus (MRSA) and Streptococcus pyogenes. [7]
Research showed that some G. lucidum extracts have stronger antibacterial activity than drugs like streptomycin and penicillin. All of this research indicates that G. lucidum suppresses the growth of numerous bacterial illnesses. [8]
Researchers tested various extracts of G. lucidum, including methanol, chloroform, and acetone, and found antibacterial activity against S. aureus, E. coli, B. subtilis, E. aerogenes, Corynebacterium diphtheria, Salmonella sp., and P. aeruginosa. [1] [9]

References

[1] Kalam, S., Pandey, A. K., and Sandhu, S. S. (2010). Evaluation of antibacterial activity of different Ganoderma lucidum extracts. J. Sci. Res. 3, 9–13
[2] Shah, P., Modi, H. A., Shukla, M. D., and Lahiri, S. K. (2014). Preliminary phytochemical analysis and antibacterial activity of Ganoderma lucidum collected from Dang District of Gujarat, India. Int. J. Curr. Microbiol. App Sci. 3, 246–255
[3] Robles-Hernández, L., Salas-Salazar, N. A., and Gonzalez-Franco, A. C. (2021). Purification and characterization of antibacterial activity against phytopathogenic bacteria in culture fluids from Ganoderma lucidum. Molecules 26, 5553. doi:10.3390/ molecules26185553
[4] Sknepnek, A., Pantić, M., Matijašević, D., Miletić, D., Lević, S., Nedović, V., et al. (2018). Novel kombucha beverage from lingzhi or reishi medicinal mushroom, Ganoderma lucidum, with antibacterial and antioxidant effects. Int. J. Med. Mushrooms 20, 243–258. doi:10.1615/IntJMedMushrooms.2018025833
[5] Radhika, R. (2021). Antibacterial activity of Ganoderma lucidum extracts against mdr pathogens. Int. J. Mod. Agric. 10, 3488–3493.
[6] Mishra, J., Rajput, R., Singh, K., Puri, S., Goyal, M., Bansal, A., et al. (2018). Antibacterial natural peptide fractions from Indian Ganoderma lucidum. Int. J. Pept. Res. Ther. 24, 543–554. doi:10.1007/s10989-017-9643-z
[7] Sande, E., Baraza, D. L., Ooko, S., and Nyongesa, P. K. (2020). Isolation, characterization and antibacterial activity of ergosta-5, 7, 22-triene-3β, 14α – Diol (22Z) from Kenyan Ganoderma lucidum. Asian J. Appl. Chem. Res. 5, 48–57. doi:10.9734/ajacr/2020/v5i130127
[8] Heleno, S. A., Ferreira, I. C., Esteves, A. P., Ćirić, A., Glamočlija, J., Martins, A., et al. (2013). Antimicrobial and demeaning activity of Ganoderma lucidum extract, p-hydroxybenzoic and cinnamic acids and their synthetic acetylated glucuronide methyl esters. Food Chem. Toxicol. 58, 95–100. doi:10.1016/j.fct. 2013.04.025
[9] Goud, N. S., Das, S. K., Ranjan, H., and Kumari, S. K. (2019). Antioxidant activity, antibacterial activity and total phenol and flavonoid analysis of Ganoderma lucidum. J. Glob. Trends Pharm. Sci. 10, 6894–6899